R3918-PNH-2021

A Randomized, Open-Label, C5 Inhibitor-Controlled Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Complement Inhibitor Treatment-Naive or Have Not Recently Received Complement Inhibitor Therapy

一項隨機分配、開放性、補體因子 5 (C5) 抑制劑對照試驗,針對未曾接受補體抑制劑治療或最近未接受過補體抑制劑療法的陣發性夜間血紅素尿症患者,評估 Pozelimab 和 Cemdisiran 併用療法的療效與安全性

PNHNCT05133531IRB: AB-CR-112-094Last updated: 5/3/2026
Trial Completed

Study Design

Study Drug

C5 inhibitor

Mechanism of Action

C5 inhibitor

Sponsor

陳彩雲

Design

III

Control Arm

Eculizumab

Criteria

Inclusion Criteria

Untreat or Eculizumab stop over 3 m or Ravulizumab stop over 6 m

Age: Phase: III

Exclusion Criteria

Enrollment

Progress0 / 0

Contact Information

Principal Investigator

Unknown

Study Nurse

李佳玲

Contact Tel

4620

臨床試驗資訊以最新版本計畫書為準 Clinical trial information is subject to the latest version of the Protocol.